Assis Brasil (Brazilian Portuguese pronunciation: [aˈsiz bɾaˈziw]) is a municipality located in the south of the Brazilian state of Acre.

Its population is 7,534 (2020 est) and its area is 4,974 square kilometres (1,920 sq mi).

The municipality contains part of the Rio Acre Ecological Station.

[1] It also contains part of the 931,537 hectares (2,301,880 acres) Chico Mendes Extractive Reserve, a sustainable use environmental unit created in 1990.

The municipality was named after Joaquim Francisco de Assis Brasil, a diplomat who was involved in the transference of Acre from Bolivian to Brazilian control after the Acre War.