Sena Madureira (Portuguese pronunciation: [ˈsẽnɐ maduˈɾejɾɐ]) is a municipality located in the center of the Brazilian state of Acre.

Its population is 46,511 and its area is 25,278 square kilometres (9,760 sq mi), making it the largest municipality in the state.

[2] It also contains part of the 931,537 hectares (2,301,880 acres) Chico Mendes Extractive Reserve, a sustainable use environmental unit created in 1990.

[5] It contains 98% of the 750,795 hectares (1,855,250 acres) Cazumbá-Iracema Extractive Reserve, established in 2002 to support sustainable use of the natural resources by the traditional population.

[6] The municipality contains about 12% of the 695,303 hectares (1,718,130 acres) Chandless State Park, created in 2004, which protects an area of rainforest with bamboos that contains various endemic species of flora and fauna.