When the local church of Davao was starting to rebuild and reorganize after the Second World War, Archbishop Clovis Thibault wanted the religious groups to take part in the reconstruction by establishing centers of learning in the archdiocese that would offer solid and formal education for children from all walks of life.

At the opening of classes, it registered 170 enrollees, consisting of 84 elementary pupils and 86 high school students.

The succeeding years saw the expansion of its curricular offering to several levels of learning to meet the needs of the youth and the community.

However, barely twelve years later, it had to be phased out due to a lack of teachers holding master's degrees, among other reasons.

[citation needed] The school maintains an active approach to social justice, including campaigning against a coal-fired power station in Davao, and in favor of restrictions on disposable plastics and junk food.

The Queen of Peace is a four-storey building that houses part of the junior and senior high school rooms.

The Queen of the Prophets is a five-storey building that houses the registrar's office, finance department room, and college and high school libraries.

The Assumption College of Davao has joined different athletic contests from the divisional, regional and even the national level.