In the film, Getafix is accidentally made insane and amnesic by Obelix, forcing Asterix to try to cure him as his village is deceived by a fraudulent soothsayer that works for the Romans.

The Romans try to capture Druid Getafix, as part of their plan to deprive a rebel village of Gauls from the magic potion that gives them super-human strength.

Knowing that Romans will quickly realise that the village is in trouble without the magic potion, Asterix and Vitalstatistix desperately attempt to have Getafix brew some.

The first English dub of Asterix and the Big Fight featured Bill Oddie, Bernard Bresslaw, Peter Hawkins, Brian Blessed, Tim Brooke-Taylor, Andrew Sachs, and Ron Moody, amongst others, and was widely seen in the UK.

The American dub is considered inferior by fans of the original due to it changing parts of the script as well as character names (Getafix is changed to "Vitamix", Vitalstatistix to "Chief Bombastix", Cacofonix to "Franksinatrix," Impedimenta to "Bonemine" (her actual French name), and Unhygienix to "Fishstix"), and general dumbing-down for an audience assumed to be unfamiliar with the characters.