[4] The AMR22 is the first car that has been overseen by new team principal, Mike Krack formerly of BMW Motorsport who replaced Otmar Szafnauer who joined Alpine.

[5][6] Dan Fallows joined the development team in April 2022, leaving Red Bull Racing to become Aston Martin's technical director.

The AMR22 had cooling vents along the entirety of the upper sidepod, the front openings of which were small boxes compared to previous cars.

[11][12] The AMR22 was part of the official pre season test in Bahrain, where 339 laps were completed at a fastest time of 1.33.821 (Vettel).

[20] Prior to the opening round of the season, Sebastian Vettel was replaced for the race by Nico Hülkenberg due his contraction of COVID-19.

To celebrate Aston Martin's 100 years in motor racing, the AMR22 featured the marque's historic badge on its nosecone for the French Grand Prix.

[25] In the race, Stroll scored the team's first point since Silverstone, after a close last lap battle with teammate Vettel.