The enhanced version of the game titled Atelier Sophie: The Alchemist of the Mysterious Book DX[b] was released for PlayStation 4, Windows, and the Nintendo Switch on April 22, 2021.

[8] A sequel, Atelier Sophie 2: The Alchemist of the Mysterious Dream released on Nintendo Switch, PlayStation 4, and Windows on February 25, 2022.

[11] The game is set in the small town of Kirchen Bell, a location with a warm atmosphere and occasional rainfall, during the dawning era of alchemy prior to it becoming a widespread art.

[15] The game was first announced to the public through pre-publication previews of Weekly Famitsu and within the 593rd volume of Dengeki PlayStation, and is directed by series director Yoshito Okamura.

[11] Musicians involved in production for the game's opening, ending and insert songs include Rurutia, Ami, Haruka Shimotsuki, Tsukiko, Okazaki Anna, and TynwaldMusic.

[32] The game sold a total of 68,106 physical retail copies across all three console platforms within the first week of release in Japan.