Athanasios Kanakaris-Roufos (Greek: Αθανάσιος Κανακάρης-Ρούφος, 1830–1902) was a Greek politician from Achaea.

He was mayor of the city of Patras from 1879 to 1883.

Together with his brother, he helped with the reformation of Patras.

During his time as mayor he ran a gaslight company in Krya Itea, planted olives southwest of downtown, opened roads, constructed Omonoia Square, ran public schools, the Markato market and constructed the race track.

He raised two sons Loukas Kanakaris-Roufos and Vasileios Roufos.