He was the son of Benizelos Roufos, a Prime Minister of Greece and Mayor of Patras, he is descended from the Rouphos-Kanakaris families with many generations of politicians and descended from southern Italy.

He married Roxani Mavromichali (Ρωξάνη Μαυρομιχάλη) and raised a son Ioannis Roufos.

During his mayoral run, he constructed and opened the Apollo Theatre, opened a public hospital, began the construction of wave braker at the Port of Patras, localized the opening of Georgiou I Square and ran the gaslight factory 1 km south-southwest of downtown.

In that situation, he tore down the castle at the spot where the theater was constructed, bakery and several buildings.

In 1891, a large fire destroyed his homes and the archives of the Rouphos family.