It was built to house knights of the Order of Saint John from the langue of Castille, León and Portugal.

The first Auberge de Castille, which was known as the vecchia alberghia di Castiglia, was built in the 1530s.

A second auberge was built in Barrack Front Street (now Hilda Tabone Street) during the magistracy of Grand Master Claude de la Sengle.

This auberge was designed by the architect Niccolò Bellavante in the traditional Maltese style, and it housed the langue until the building of a new Auberge de Castille in Valletta in 1574.

The building still exists, but it has been heavily altered over time, and only a quoin and some windows with Melitan mouldings remain of the original auberge.