Autoimmune polyendocrine syndromes (APSs), also called polyglandular autoimmune syndromes (PGASs)[3] or polyendocrine autoimmune syndromes (PASs), are a heterogeneous group[4] of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected.

There are three types of APS, and there are a number of other diseases which involve endocrine autoimmunity.

IPEX syndrome is inherited in males by an X-linked recessive process.

The FOXP3 gene, whose cytogenetic location is Xp11.23, is involved in the mechanism of the IPEX condition.

[11][1] Diagnosis for type 1 of this condition for example, sees that the following methods/tests are available:[2] For this condition, differential diagnosis sees that the following should be considered:[12] Immunosuppressive therapy may be used in type I of this condition.