[6] Symptoms of more severe hypersensitivity include both local and generalized hives; feelings of faintness or impending doom; angioedema; nausea and vomiting; abdominal cramps; rhinitis; bronchospasm; and anaphylaxis.

Type IV responses typically include erythema, blistering (forming vesicles and papules), itching, and crusting at the point of contact.

[12] On December 19, 2016, the FDA officially banned the use of powdered gloves in the US healthcare setting, citing the unnecessary burden of potential injury due to allergy.

[13] General latex avoidance protocols have been put in to place in healthcare settings in the US and many other developed countries with the switch to nitrile gloves.

[14] In particular, individuals with chronic health concerns that lead to repeated surgeries or catheterizations thus experience greater exposure to latex allergens and may develop an allergy.

[15] Outside of hospital environments, latex allergy may develop in amateur and professional athletes whose sports equipment includes natural rubber, such as swimsuits or running shoes.

[16] The sensitization to latex in athletes may be accelerated by the use of topical analgesics and other agents that diminish the skin barrier and increase contact.

[17] It has also been hypothesized that young children may develop a latex allergy due to exposure in the home and school environment from objects such as rubber balloons, boots, gloves, and toys.

[22] Fruits (and seeds) involved in this syndrome include banana, avocado, chestnut, kiwifruit, mango, passionfruit, fig, strawberry, papaya, apple, melon, celery, potato, tomato, carrot, and soy.

[36][37] Latex allergy is uncommon in the general population, at least compared to high-risk groups such as hospital workers and spina bifida patients.