[7] Enterococci from urinary tract infections and coagulase negative staphylococci can also be causative agents.

[5] The mechanism of subacute bacterial endocarditis could be due to malformed stenotic valves which, in the company of bacteremia, become infected via adhesion and subsequent colonization of the surface area.

[9] On the other hand, in cases of acute bacterial endocarditis the organism can colonize on the healthy heart valve, causing the disease.

[10] Subacute bacterial endocarditis can be diagnosed by collecting three blood culture specimens over a 24-hour period for analysis,[4] also it can usually be indicated by the existence of: The standard treatment is with a minimum of four weeks of high-dose intravenous penicillin with an aminoglycoside such as gentamicin.

[2] Leo Loewe of Brooklyn Jewish Hospital was the first to successfully treat subacute bacterial endocarditis with penicillin.