Some of its sections came to be occupied by a missing arm of the Guadalquivir River, from which the Alameda de Hércules crossed the Campana, the Plaza Nueva and emptied into the El Arenal area.

Avenida de la Constitución acquired economic importance from the late Middle Ages, mainly as a result of the construction of the new major mosque (inaugurated in 1176) and the subsequent Castilian conquest in 1248.

[1] After the discovery of the Americas, and the choice of Seville as the exclusive port of the Indian trade, the commercial activity of the city increased, the steps of the cathedral served as a meeting place for merchants for their negotiations, where trips were advertised projected and products arrived from overseas.

During the second half of the sixteenth century, the cathedral chapter, to avoid the excesses committed in the area by merchants, installed columns with chains around the temple and hired bailiffs to prevent the passage of pack animals on the street.

[2] The current Avenida de la Constitución brings together in a single route as a result of several transformations proposed since 1863 and implemented in 1911 by the then mayor, Antonio Halcón y Vinent, within the framework of the reforms linked to the Ibero-American Exposition of 1929.