[2] There is a single species in this genus: Infectious bursal disease virus, which infects chickens and other fowl.

[6] Avibirnaviruses are non-enveloped, and their single shelled icosahedral capsid exhibits a T=13 symmetry.

[5] The viral protein in conjunction with VP5 acts as an apoptotic inducer, which causes affected cells to become cytotoxic.

[9] This activation leads to an increase in reactive oxygen species in the affected cells.

[7] Its helps to regulate VP2 apoptosis by inhibiting phosphorylation of PKR and eukaryotic initiation factor 2 (eIF2).

[7] VP4 will additionally take over a glucocorticoid-induced leucine zipper protein (GILZ) that will allow for viral growth and block immune response of host cell.

[10] The inhibition will be aided by VP2, which will close the channel allowing for proliferation of the virus in host cells.

[5] The project domains can be viewed to see the variation of the virus through amino acid substitutions.

[11] Serotype 1 is pathogenic to chickens especially at 3 to 6 weeks of age and seen to be more virulent in lighter breeds.

[11] One receptor that the virus will bind is surface immunoglobulin M, which specifically interacts with the light chains of the antibody.

[9] The peptide causes the membrane to become permeable by forming pores, which allow for PEP46 entry depending on calcium gradient.

[9] If the inner calcium gradient is low, then it is thought to enter V-ATPase positive vesicles by endocytosis and uncoated for entry into the cytosol.