The northeast of the valley contains Marana on I-10, the Pinal Airpark, an aircraft storage park, and other communities along I-10.

Much of these ranges to the West of Avra Valley are protected in Ironwood Forest National Monument.

South of Roskruge, Arizona Route 86 enters the valley from the Tohono O'odham Nation to the west.

The north of the Avra Valley narrows at the Silver Bell Mountains and Marana to the east.

Saguaro National Park protects the northern Tucson Mountains in its West Unit bordering Avra Valley.