Axoniderma mexicana is a species of demosponge in the family Cladorhizidae.

[1] It is known from type specimens found around Mexico.

The generic name, Axoniderma, is derived from the Ancient Greek ἄξων (áxōn), "wheel", and δέρμα (dérma), "skin".

[2] The specific epithet, mexicana, refers to Mexico, where the species' holotype was discovered.

This article about a demosponge is a stub.