In particular, the Khyber Pakhtunkhwa province was in dire need of health reforms - a decision was thus made in 1972 to construct another medical college outside of the Peshawar region.

The first batch consisting of 100 students (class of 1984) was accommodated at the Education Extension Centre, while the present college campus and teaching hospital were later on constructed north of the town.

[1] On 20 December 2023, Prime Minister Anwaar ul Haq Kakar, during a speech to the 46th annual meeting of Association of Physicians of Pakistani Descent of North America (APPNA), announced that AMC would be upgraded to a medical university.

The College of Physicians and Surgeons of Pakistan has recognized many of its departments for post-graduate training in Medicine, Surgery, Obstetrics & Gynaecology and Pathology.

The Royal College of Obstetricians and Gynaecologists of Britain has granted recognition to the Department of Obstetrics and Gynaecology at AMC for clinical training of MRCOG candidates.

[1] The medical school building has four air-conditioned, spacious lecture halls with sophisticated audiovisual teaching aids, well-equipped laboratories and museums.

The campus also provides hostel accommodation for up to 500 medical students, 300 internees, 100 nurses, and a colony comprising 10 flats for non-teaching staff.

Due to its unique "crossroad" location, Ayub Medical College has one of the most ethnically diverse campuses in Pakistan with students from various backgrounds including, Balochs, Pashtuns, Hindkowans, Chitralis, Punjabis, Saraikis, Kashmiris, Kalash, Burusho, Shina and Baltis.