Azeb Mesfin Haile (Amharic and Tigrinya: አዜብ መስፍን ኃይሌ; born 21 December 1966)[1] is an Ethiopian politician who was the second First Lady of Ethiopia from 2001 to 2012.

[3] In early 2009, she was appointed CEO of the Endowment Fund for the Rehabilitation of Tigray by its head Abadi Zemu.

She is the daughter of an Amhara peasant farmer father Mesfin Haile and a Tigrayan mother Konjit Gola.

Her role has at times been controversial, with some members of Ethiopian diaspora alleging that, during the period in which she was an executive at the parastatal Mega Corporation, she was involved in "the impropriety of mingling public, private and party-owned businesses.

"[8] However Azeb is also known for her work to teach rural Ethiopians about the issues of HIV/AIDS Her appearance at a special ceremony to honor the First Ladies of Africa for their efforts against the spread of HIV/AIDS held by Georgetown University of Washington DC on 15 January 2007 was met by protests of exiled Ethiopians.