Up until the Cuban Revolution, the organisation's efforts centered on combatting antisemitism and conducting philanthropic activities on behalf of the Jewish community in Cuba.
Under Galen's leadership, the organisation's mission changed to reflect the new situation facing the community.
According to Galen, combatting antisemitism in Cuba was no longer a priority concern, additionally, the community did not have the financial capacity to raise funds for philanthropic efforts.
[1] In 1997, B'nai B'rith International formed a Committee on Cuban Affairs.
[2] In one report, B'nai B'rith estimated that the organisation's relief work included exporting over hundreds of thousands of dollars of medical textbooks and wheelchairs to Cuban hospitals and $6,000,000 of medicine, Judaica and other supplies to the Jewish community in Cuba.