In scientific computing, BLIS (BLAS-like Library Instantiation Software)[2][3][4][5] is an open-source framework for implementing a superset of BLAS (Basic Linear Algebra Subprograms) functionality for specific processor types that was awarded the J. H. Wilkinson Prize for Numerical Software in 2023.

These native interfaces provide access to BLAS-like functionality that is not supported by, but closely related to, operations found in the BLAS (and CBLAS).

The framework is developed and supported by the Science of High-Performance Computing (SHPC) group of the Oden Institute for Computational Engineering and Sciences at The University of Texas at Austin and the Matthews Research Group at Southern Methodist University.

BLIS yields high performance on many current CPU microarchitectures in both single-threaded and multithreaded modes of execution.

[8] The framework achieves high performance by employing specialized kernels (typically written in GNU extended inline assembly syntax) along with cache and register blocking through matrix operands.