N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is an organosilicon compound.

It is a colorless liquid that is very sensitive to traces of water or alcohols.

It is often used to convert hydroxyl groups to trimethylsilyl ether groups (Me = CH3): These silylated derivatives are amenable to analysis or further manipulation.

Siloxanes are invariably more volatile than their hydroxyl precursors, and thus they can be more easily analyzed with gas chromatography.

[1] This reagent was first reported in 1968.