B-type inclusions, formerly known as Guarnieri bodies /ɡwɑːrnˈjɛəri/ are cellular features found upon microscopic inspection of epithelial cells of individuals suspected of having poxvirus[1] (e.g. smallpox[2] or vaccinia).
The absence of Guarnieri bodies cannot be used as to rule out smallpox, however, as more sensitive test need to be performed.
B-type inclusions are the sites of viral replication and are found in all poxvirus-infected cells, unlike A-type inclusions which are more strongly eosinophilic and only found in infections with certain poxviruses.
[3] They are named after the Italian physician Giuseppe Guarnieri.
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