Councilman body

[3] The dying cells release varying amounts of closed, subcellular pieces that are often large for extracellular vesicles that may include forms of protein, DNA and RNA fragments, chromatin, lipids, cytosol, and organelles.

[6] Councilman bodies are often named for the hepatocytes undergoing apoptosis, which occurs in the portal tracts and lobules of the liver.

[7] Through the use of double immune fluorescence methods, HBsAg and/or HBcAg (hepatitis B core antigen) are present in Councilman bodies in the liver.

With a bright field microscope, Councilman described typical, discrete, necrotic lesions in human hepatic cells of those infected with yellow fever.

All deceased primates were submitted for necropsy and yellow fever diagnosis for the Brazilian Ministry of Health's surveillance program.

The official diagnosis included that the liver contained hepatocellular degeneration and necrosis with Councilman bodies and intracytoplasmic lipid.

His liver samples showed Councilman bodies in the hepatocytes in their intermediate zones that revealed eosinophilic cytoplasmic coagulation.

[10] Five adults with hepatitis, two children with hepatoma, and three mongrel dogs provided tissue samples for study have an auxiliary liver transplant into the pelvis.

The progression of the acute hepatitis in the LEC rat was observed, showing only a few enlarged hepatocytes and Councilman bodies in its early life.

Councilman body (upper-right) and ballooning degeneration (centre-left). H&E stain .
Apoptotic body
Apoptosis of the liver of a mouse
William Thomas Councilman
Rat liver comparison between normal (A) vs. acute hepatitis (B) cells