The song marks the first collaboration between the two artists, and they later reunited in 2021 on Lil Durk's song "Should've Ducked", a track off of the deluxe edition of his sixth studio album, The Voice.

[2] "Back in Blood" debuted at number 93 on the Billboard Hot 100.

[3] On February 11, 2021, Pooh Shiesty performed a piano version of "Back in Blood" (without Lil Durk) alongside "Guard Up", two songs from his mixtape, live on Audiomack.

[5] Shiesty performed the song on April 14, 2021, on The Tonight Show Starring Jimmy Fallon, with Durk assisting him.

[6] Remixes of "Back in Blood" have been performed by Asian Doll,[7] Cupcakke,[8] Pooh Shiesty's labelmate K Shiday[9] and Joyner Lucas.