Written and produced by Motown's main production team Holland–Dozier–Holland, "Back in My Arms Again" was the fifth consecutive and overall number-one song for the group on the Billboard Hot 100 pop singles chart in the United States from June 6, 1965, through June 12, 1965,[1] also topping the soul chart for a week.

The song's middle eight is almost identical to a later Holland-Dozier-Holland hit, The Isley Brothers "This Old Heart of Mine (Is Weak for You)".

[24][25] The song almost made the Hot 100 in 1983 via a remake on Motown's Gordy label by female vocal group High Inergy, whose 1977 debut album Turnin' On had yielded a Top 20 hit in ("You Can't Turn Me Off") and elicited numerous comparisons with the Supremes.

[32] "Back in My Arms Again" has also been remade by the Michael Stanley Band (on Greatest Hints, 1979),[33]Nicolette Larson (as "Back in My Arms" on In the Nick of Time in 1980), by Michael Bolton (on his eponymous 1983 album), by The Forester Sisters (on Perfume, Ribbons & Pearls in 1986), and by Colin James (on the American Boyfriends soundtrack album in 1989).

[34] The song was recorded by the all-female American rock group Fanny in early 1973 but their version, produced by Todd Rundgren, remained unreleased until 2002, when it appeared on Rhino Handmade's limited-edition Fanny anthology First Time In A Long Time: The Reprise Recordings.