Each year, the show features marquee-name comic book creators past and present, publishers, charitable organizations, and vendor booths offering genre-related items, including comic book back-issues, limited edition collectible items such as Toon Tumblers and clothing, videos/DVDs, etc.

Founded by Marc Nathan, owner of Cards, Comics, and Collectibles of Reistertown, Maryland, the show was originally a one-day show[2] held at the Sheraton Hotel in the Chartley Shopping Center,[3] located in the Baltimore suburb of Towson, Maryland.

[citation needed] An annual Yearbook, featuring renderings by attending artists, became a part of the show in 2012, featuring Frank Cho's Liberty Meadows characters, followed by Stan Sakai's Usagi Yojimbo in 2013 and Matt Wagner's Grendel in 2014.

A scavenger hunt is also associated with the Yearbook, where attendees who get a pre-defined number of contributor autographs receive prints that were not part of the book, featuring characters from that year's theme by other attending artists.

[citation needed] The 2020 Comic-Con was cancelled due to the COVID-19 pandemic and rescheduled for the same dates as a virtual event.