[2] Bush settled in the Denver area and became a member of the board of directors of Denver-based Silverado Savings and Loan from 1985 to 1988 during the S&L crisis of the 1980s.

[6] Since his father George H. W. Bush was Vice President of the United States, his role in Silverado's failure was a focal point of publicity.

[7][8] The U.S. Office of Thrift Supervision investigated Silverado's failure and determined that Bush had engaged in numerous "breaches of his fiduciary duties involving multiple conflicts of interest."

To fund Ignite!, Bush raised $23 million from US investors, including his parents, as well as businessmen from Taiwan, Japan, Kuwait, the British Virgin Islands and the United Arab Emirates, according to documents filed with the Securities and Exchange Commission.

[citation needed] Bush's relationship with the late controversial oligarch Boris Berezovsky, a political enemy of Russian President Vladimir Putin who at the time of his death had been under indictment for fraud in Russia and an applicant for asylum in the United Kingdom,[12] has been noted in the media.

The company, Kopin Corporation of Taunton, Massachusetts, announced on the same day good news about a new Asian client that sent its stock value soaring.

"[20] Speaking at a Saudi Arabian economic forum in January 2002, Bush referred to growing anti-American sentiment in Arab countries and said the two peoples must communicate better.

[21] Bush frequently travels to the Middle East, Europe and Asia to negotiate deals and raise capital for various businesses.

[23][24] In 2001, Neil Bush incorporated an investment firm called LehmanBush with veteran China lawyer Edward Lehman.

[28] The purpose of The George H. W. Bush Foundation for U.S.-China Relations seeks to advance U.S.-China relations in ways that reflect the ethos and values of President George H. W. Bush, whose visionary, wise, deft and steady stewardship of the U.S.-China relationship during his tenure as president was exemplary of the highest attributes and values of true statesmanship.

Neil Bush is the chairman of Points of Light, an international nonprofit that works to increase volunteerism in the world.

[29] Points of Light has approximately 250 affiliates in 22 countries and partnerships with thousands of nonprofits and companies dedicated to volunteer service around the world.

[30][31] Bush was a founding director, along with Cardinal Joseph Ratzinger (the future Pope Benedict XVI), of the Foundation for Interreligious and Intercultural Research and Dialogue (FIIRD).

[23] In 2002, Neil Bush told the New York Post that he "endured his own Ritalin hell seven years ago when educators in a Houston private school diagnosed his son, Pierce, (then) 16, with Attention Deficit Disorder (ADD) and pushed medication."

Also that year, Bush testified before a hearing of the United States Congress to speak out against overmedicating children for learning disorders.

"[33] Neil Bush (along with filmmaker Michael Moore) is credited in the cast of a 2005 documentary film, The Drugging of Our Children[34] directed by Gary Null.

Bush's divorce deposition gained public attention when he admitted to several sexual encounters in Thailand and Hong Kong.

[43] Bush's son Pierce was a candidate for the U.S. House of Representatives in 2020 from Texas' 22nd district, but finished third in a fifteen-way primary.