Barrs Run is a 2.55-mile-long (4.10 km) 2nd order tributary to Tenmile Creek, in Washington County, Pennsylvania.

Barrs Run rises about 0.25 miles east of Marianna, Pennsylvania.

[3] Barrs Run drains 2.68 square miles (6.9 km2) of area, receives about 40.6 in/year of precipitation, has a wetness index of 310.46 and is about 66% forested.

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