Tenmile Creek is a stream in Washington and Greene Counties, Pennsylvania, USA.

Tenmile Creek was so named on account of frequent branches, occurring about every 10 miles (16 km).

[1] The major tributary of Tenmile Creek is South Fork Tenmile Creek, which rises in western Greene County and flows generally east entering Tenmile Creek at Clarksville, Pennsylvania.

The watershed is roughly 24% agricultural, 68% forested and the rest is other uses.

[7] South Fork Tenmile Creek has a number of smaller tributaries, including Grimes Run on the left, which rises in central Greene County and flows southeast entering South Fork Tenmile Creek northeast of Morrisville, Pennsylvania.