The basal lamina is a layer of extracellular matrix secreted by the epithelial cells, on which the epithelium sits.

Although found beneath all basal laminae, they are especially numerous in stratified squamous cells of the skin.

Some of the matrix molecules (of the basal lamina) mediate synaptic adhesion in neuromuscular synapses.

These genes are important in collagen IV synthesis and basement membrane formation.

In individuals with this syndrome the basement membrane in structures such as the glomerulus, ears, and eyes does not function properly, causing symptoms such as blood in the urine, loss of hearing, and vision problems.