Baseball was contested at the 1946 Central American and Caribbean Games in Barranquilla, Colombia.

The number of athletes a nation entered is in parentheses beside the name of the country.

[1] Willy Miranda, a future Major League Baseball with the New York Yankees and Baltimore Orioles, made his debut with the Cuba national team in the 1946 Games, hitting .250.

[2] The group stage featured a round robin format to determine the medal winners, similar to the format of the 1938 tournament.

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