The battle of Aguadulce took place during the Colombian Thousand Days' War, between Liberals and Conservatives.

It occurred between February 23 and August 27, 1901, and ended in an overwhelming victory on the part of the Liberal army under the command of General Benjamin Herrera over the Conservative army based in the city of Aguadulce, Coclé under the command of General Francisco Castro.

More than half of the Conservative defenders became casualties due to hunger, fever, and dysentery during the 29-day siege.

Due to the supply situation and incessant raids by the besieging army, General Berti finally surrendered Aguadulce on August 27, 1901, under severe conditions put forward by the Liberals.

In total 13 generals, 300 officers and more than 3,000 soldiers, as well as a large amount of weapons, were surrendered to the Liberal forces.