The Dutch production team would continue with a domestic fifth season in the Netherlands, again under the title of Holland's Next Top Model.

A thirteenth contestant, Melanie Weterings, was added to the cast as a result of having won a separate "wildcard" competition.

Each episode covered the events of roughly a week of real time (however, while overseas, an episode roughly covered three to four days, totalling two weeks of filming abroad), and featured a fashion challenge, photo shoot or commercial, judging, and critique of each contestant and her performance by the judging panel led by Daphne Deckers, and the elimination of one or more contestants.

Each episode was usually associated with a theme in the world of modeling, such as dealing with the press in interviews, selling a commercial product, appearing in a runway show or going on "go sees".

She received some prize, such as clothing, a night out, or an advantage at the next photo shoot, and she was usually allowed to share the benefits with a certain number of other contestants of her choice.