[5] It is not recommended in those with a history of penicillin allergy or those with syphilis involving the nervous system.

[3] It is in the penicillin and beta lactam class of medications and works via benzylpenicillin.

[3][5] The benzathine component slowly releases the penicillin making the combination long acting.

The Army in particular has a policy to inject all recruits if not allergic, though supply issues and individual base choices have reduced the coverage.

A retrospective analysis shows that it reduces the rate of all-cause acute respiratory disease by 32% among Army recruits.