The station was opened in 1881 under the name of Zentralviehhof, as the vast area south of the station then was the site of Berlin's central slaughterhouse that received animals by rail here.
An over 400-metre (0.25 mi) long pedestrian bridge (called the Langer Jammer, i.e. "Long Misery") crossed the processing plant connecting the station with the Friedrichshain residential areas.
The station was renamed in the 1970s, while in 1991 the slaughterhouse finally closed.
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