He played college football for the Fresno State Bulldogs,[1] earning first-team All-American honors in 2001.

Berrian was born in Spain,[2] and grew up in Winton, California, while both of his parents served at Castle Air Force Base.

He was known as an explosive two-way starter for Atwater High School, which went 13–1 his senior year, after he caught 53 passes for 1,276 yards and 16 touchdowns.

[5] Berrian spent a majority of his early years with the Bears as a back-up wide receiver and return specialist.

Berrian returned to play during the Bears' NFC Divisional game against the Carolina Panthers, but eventually he was forced to leave after sustaining an injury.

Berrian finished the regular season as the Bears' second leading wide receiver, only a few catches behind team leader Muhsin Muhammad.

He also made a clutch, 33-yard diving touchdown reception behind a jumping Fred Thomas, giving the Bears an eleven-point lead, which contributed to their 39–14 victory.

In 2009, with the acquisition of 20-year veteran quarterback Brett Favre, Berrian became one of the deep threats of the wide receiver core along with Sidney Rice, Percy Harvin, and Visanthe Shiancoe.

[11] In November 2008, Bernard pledged to donate up to $10,000 to Second Harvest Heartland, Minnesota's largest hunger-relief organization, to provide turkeys to hungry inner-city families for the holiday season.

[14] During a Monday Night Football appearance, Muhsin Muhammad revealed that Berrian's nickname is "B-twice".

[16] He is friends with Chad Johnson and appeared occasionally on his dating show Ochocinco: The Ultimate Catch.