Bernice is a town in Delaware County, Oklahoma, United States.

"[5] Bernice was founded in 1912, after Rose Mode and his partner, Charles Lee, bought 60 acres (24 ha) of land in the Horse Creek Basin of northwestern Delaware County.

A post office was established on February 12, 1913, and the town soon become a local agricultural center.

Businesses included a bank, a milliner, a grain elevator, a sawmill, a hotel, a flour mill and three general stores.

[5] At present, the town serves as a vacation spot for many residents of surrounding communities.

Indian Hills Resort, the oldest recreational business in the town, was established in 1940.

Bernice State Park, approximately one-half mile east of town, across the Neosho River, also attracts vacationers.