Arkansas Highway 21 leads north from Berryville 16 miles (26 km) to the Missouri line.

According to the United States Census Bureau, Berryville has a total area of 6.1 square miles (15.8 km2), all land.

[8] As of the 2020 United States census, there were 5,682 people, 2,009 households, and 1,269 families residing in the city.

Saunders' Museum, which has guns used by outlaws such as Pancho Villa, Billy the Kid, and many others, as well as other items of interest, is located in the center of town.

Berryville is the home of handgun manufacturing companies of Nighthawk Custom and Wilson Combat, as well as the International Defensive Pistol Association, a body that sanctions practical shooting competitions that emphasize real-world self-defense scenarios.

Little Portion Hermitage, a community founded by Christian musician John Michael Talbot, is located outside of Berryville.