[2] She was the youngest of three daughters born to Elizabeth Browning, a graduate of Cornell and teacher of Latin, and Merle Davis James, an artist and printer.

[2] Betsy Wyeth became her husband's business manager, negotiating commissions, organizing shows, and maintaining his catalogue raisonné.

[2] She helped to save a 19th-century gristmill by encouraging a neighbour, George Weymouth, to buy it and turn it into a museum.

[1] In Knox County, Maine, she bought three islands (Southern, Allen, and Benner), on one of which she restored a lighthouse.

[2] The sail loft became the subject of one of Andrew Wyeth's paintings, and was renamed Goodbye by Besty following his death.

[7] Betsy Wyeth was a founding member of the Chadds Ford Historical Society, and a driving force in the creation of Island Journal.

[1] Betsy Wyeth died aged 98 on 21 April 2020 at her home in Chadds Ford, Pennsylvania.

[9] Between 2020 and 2021, the Brandywine Museum of Art paid tribute to Betsy Wyeth's legacy with a display of 20 drawings and paintings of and about her.