In 1360–1379, Bezdružice was owned by knight Bušek and it was in these times, when a small stone castle was built.

During the Thirty Years' War, around 1646, the town and the castle were burnt down by the invading Swedish army.

However, the population declined during and after World War II, mainly following the expulsion of local German inhabitants.

[5] In 1949, Bezdružice lost the town status and was incorporated into the Tachov District.

[4] Bezdružice is the starting point and terminus of the railway line from/to Radnice via Plzeň.