On 29 May 1869 the line from Darmstadt via Riedstadt-Goddelau and Biblis to the Rosengarten station, on the opposite side of the Rhine to Worms, was opened by the Prime Minister of the Grand Duchy of Hesse, Reinhard Carl Friedrich von Dalwigk.

[5] In October 1879 the line was extended via Waldhof to Mannheim Neckarstadt where it ended not at Mannheim Hauptbahnhof, but at the Riedbahnhof (Ried Railway station), north of the present Kurpfalz bridge.

Regional services on the next Ried Railway are organised by the Rhein-Main-Verkehrsverbund (RMV) and the Verkehrsverbund Rhein-Neckar (VRN).

Biblis station is served by Regional-Express service RE 70 between Mannheim and Frankfurt.

Regionalbahn trains to Mannheim and Karlsruhe are expected to be replaced by Rhine-Neckar S-Bahn services.