The Big Arsenal, in Dutch: Groot Tuighuis, in 's-Hertogenbosch, Netherlands, is also known as Old St. James Church, or Oude Sint Jacobskerk.

The main 1430 altar was dedicated to James the Great, and was built together with a refuge for pilgrims to Santiago de Compostella.

The Provincial society for arts and sciences in North Brabant, Provinciaal Genootschap van Kunsten en Wetenschappen in Noord-Brabant, was a society dedicated to promoting Arts & Sciences.

[7] It started to look for a building, and found the Big Arsenal (Groot Tuighuis).

The solid floors which had been created inside the building, made it the perfect place for the museum with its large library.

The military authorities agreed to hand the Big Arsenal to the society for a small lease of 200 guilders.

His main contribution is the current western façade, which made a suitable entrance.

The move to the Big Arsenal was crucial for the museum, because it got a space to start its collections and to exhibit them.

[9] In September 1967 a large exposition of works by Hieronymus Bosch was held in the museum on account of the 450th anniversary of his passing.

[10] In these decades the activities of the museum greatly increased, as did the cultural ambitions of the city.

A study of the required housing for the museum then showed that the church would not be sufficient for future developments.

From 1988 onwards the church was used by the municipal department for Building History, Archaeology and Monuments (BAM).

The most used parts of the physical archive, about 3 kilometers of paper, would also move to the Arsenal.

In 2019 there was an exposition about the prosecution of local Sinti and Roma during World War II.