Big Bone is an unincorporated community in southern Boone County, Kentucky, United States.

It was soon discovered that, due to the relatively low salinity of the springs, 500 to 600 gallons of water were required to produce a single bushel of salt.

[5]: 10–11 The Clay House, a resort hotel, opened nearby in 1815, offering visitors an opportunity to bathe in the supposedly medicinal salt mineral springs.

The mouth is at the division of Boone and Gallatin Counties, Kentucky, near the site of Big Bone Island.

[13] It has been stated that the decisions and actions of the U.S. Army Corps of Engineers on January 27, 1978, at the Markland Dam, caused the ice jam to break.

[13] This was characterized as being perhaps the worst disaster in modernity on the Ohio River,[14] and caused significant damage, with entire docks, barges and boats crammed against or forced through the Markland dam.