Its source is located just north of the intersection of Georgia State Route 9 and Georgia State Route 20, in Forsyth County, about 1 mile (1.6 km) directly south of downtown Cumming.

Vickery Creek is named after a Cherokee woman named Sharlot Vickery who lived in present-day Roswell and owned much of the land around the creek.

Much of the land east of the creek and west of Grimes Bridge Road in Roswell forms the Vickery Creek unit of the Chattahoochee River National Recreation Area.

Upstream of the covered bridge and Ivy Mill is a man-made waterfall.

[citation needed] Hog Wallow Creek is a major tributary that enters in Roswell, just north of the Chattahoochee River.