63312111ENSG00000182492ENSMUSG00000031375P21810P28653NM_001711NM_007542NP_001702NP_031568Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon.

[6] Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS), with DS being more abundant in most connective tissues.

Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage.

[8] The composition of GAG chains of biglycan and decorin originating from the same tissue has been reported to be similar.

[17] Biglycan is a particularly important proteoglycan for binding to lipoprotein in human blood vessels, thus being a significant cause of atherosclerosis.