The crystal structure of CETP is that of dimer of two TUbular LIPid (TULIP) binding domains.

CETP contains two of these domains that interact head-to-head via an interface made of 6 beta-sheets, 3 from each protomer.

[10] Rare mutations leading to reduced function of CETP have been linked to accelerated atherosclerosis.

[11] In contrast, a polymorphism (I405V) of the CETP gene leading to lower serum levels has also been linked to exceptional longevity[12] and to metabolic response to nutritional intervention.

[11] Elaidic acid, a major component of trans fat, increases CETP activity.