1OC0, 1S4G, 1SSU, 2JQ8, 3BT1, 3BT2, 4K24744822370ENSG00000109072ENSMUSG00000017344P04004P29788NM_000638NM_011707NP_000629NP_035837Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is synthesized and excreted by the liver, and abundantly found in serum, the extracellular matrix and bone.

It also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpins (serine protease inhibitors).

On occasion, the protein is cleaved after arginine 379, to produce two-chain vitronectin, where the two parts are linked by a disulfide bond.

High plasma levels of both PAI-1 and the urokinase receptor have been shown to correlate with a negative prognosis for cancer patients.

Cell adhesion and migration are directly involved in cancer metastasis, which provides a probable mechanistic explanation for this observation.