[5] Since 2019, Bush has been the host of the syndicated newsmagazine TV show Extra, a year after the series moved from NBC to Fox.

[2] He was also a four-year letterman and a two-time co-captain as a junior and senior with the Mules' men's lacrosse team.

[12][13] Bush joined Access Hollywood, a daily entertainment news magazine, as East Coast correspondent in December 2001.

While working at Access Hollywood, he was present at high-profile red carpet events including the Golden Globes, Grammys, and Academy Awards, and hosted ABC's live pre-show for the 2004, 2005 and 2006 Academy Awards and the 2006 Emmy Red Carpet Special.

He and Vieira both had credited cameos as hosts of fictional game shows in the 2004 remake of Ira Levin's 1972 satirical thriller The Stepford Wives.

[13] The show, which airs evenings Monday through Friday, focuses on the top entertainment stories and personalities in the news, and features celebrity guests and listener calls.

Bush co-hosted the Miss Universe pageant four times: in 2003 and 2004 with Daisy Fuentes; in 2005 with fellow Access Hollywood co-anchor Nancy O'Dell; and in 2009 with Claudia Jordan.

After the 65th Annual Golden Globe Awards of 2008 were cancelled as a result of the 2007–08 Writers Guild of America strike, Bush co-hosted the 65th Annual Golden Globe Awards Announcement press conference with O'Dell on January 13, 2008.

[13] "He's a furious, inventive interviewer, unafraid of playing the fool in exchange for a true reaction", opined the writer of the accompanying magazine profile.

Bush and Hoover traveled together to the UK to cover Prince William's wedding to Catherine Middleton, as part of the NBC team coverage.

[19] When details of Lochte's story began to fall apart, Matt Lauer re-interviewed the swimmer in a move that was seen as a snub to Bush.

[19] Bush garnered attention once again after he and Al Roker got into an argument during Olympic coverage on Today after Lochte was exposed.

Bush is heard laughing about Trump's failed effort to seduce a married woman, and joining in by commenting on actress Arianne Zucker's appearance, calling her "hot as shit.

[28][29] After The New York Times reported in late November 2017 that Trump had privately told people, including a sitting senator, that the voice on the tape was not his, Bush published an op-ed in the paper on December 3, reaffirming that the voice in the tape was the president's and accusing him of engaging in revisionist history.

Bush replaced Mario Lopez at the start of the 26th season on September 9, 2019, in a revamp of the show, which was originally to be renamed ExtraExtra.

[34][35] In 2024, Bush competed in season 11 of The Masked Singer as the wild card contestant "Sir Lion".

[38] Through his mother, Bush is a descendant of Louis DuBois, who fled religious persecution in France and settled in what was then the Dutch Colony of New Amsterdam; he helped found the town of New Paltz, New York.