The character was created by Stan Lee and Steve Ditko and first appeared in The Amazing Spider-Man #6 (November 1963).

After Curt transforms into the Lizard, he attacks and attempts to eat Billy before Spider-Man returns him to normal.

[1] In subsequent appearances, Billy is menaced by the Lizard and other villains before moving in with his aunt after Martha dies from cancer.

[7] An alternate universe variant of Billy Connors who became a separate incarnation of the Lizard appears in What If?

[8] Billy Connors appears in a deleted scene that was cut from The Amazing Spider-Man, portrayed by Miles Elliot.