BioPlex

[1][2][3] It is the result of collaborations between Harvard Medical School and Biogen.

[4] BioPlex 2.0 extended those observations to detect over 29,000 new interactions.

[5] The basic technology is to express a "bait" protein in human cells.

The interacting prey proteins are identified using mass spectrometry.

Determining the interaction partners of poorly characterized proteins can provide clues to the function of those proteins, and knowing which "protein community" a disease gene resides in can give better context for its action.